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Material
Medical products with PLGA capsule technology
Application to Balloon Catheter/Stent
- The drug can be laminated with a higher content to the medical device.
- The drug can be delivered to the cell with nanosized effect. (The improvement of cell target tropism)
By this technology, PLGA nanospheres laminated on the surface of the balloon catheter/the stent, the PLGA nanospheres will be effectively ingested into a cell through vessel wall, the rate of restenosis, the necessity and the risks of the retreatment can be reduced.
Application to Dry Powder Inhalation(DPI)
The Composite PLGA nanospheres can improve their own preservation stability, handling ability and inhalation characteristic.
The Flow of Contrcted Research System
Buissiness Model (Medical Products and Device)
Pinpoint Delivery System for Anti-cancer Drug!
One of DDS(Drug Delivery System) performances using PLGA nanoparticles Improvement of survival rate on model mice for liver-cancer by DDS sheet containing anti-cancer drug A loaded PLGA nanoparticles.
Frozen tissue section(24hrs after administration)
 |
 |
| Attached DDS sheet contained with PLGA nanoparitcles |
Intraperitoneal Administration of PLGA nanoparicles suspension |
| Data from Prof. Yamamoto of Aichi Gakuin Univ. | |
| Administered Samples （dose of anti-cancer drug A） |
Improvement of Survival Rate1) |
|---|---|
| Drug solution administered by i.p（50μg）n=13 | Not available |
| Attached sheet containing drug（8.75μg）n=12 | Not available |
| Attached sheet containing drug（27.1μg）n=12 | Available (power of DDS sheet) |
| Attached sheet containing drug loaded PLGA nanoparticles（8.0μg）n=12 | Available (power of PLGA nanoparticles) |
１）Significant difference v.s. control (saline solution administered by i.p., n=13); α<0.01, Mann-Whitney test, 60 days (max) after administration
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